Development of injectable bioceramic drug delivery system for solid tumor treatment

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Haig, J. (2017). Development of injectable bioceramic drug delivery system for solid tumor treatment. Unc Charlotte Electronic Theses And Dissertations.
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Abstract

According to the national cancer institute "In 2016, an estimated 1,685,210 new cases of cancer will be diagnosed in the United States and 595,690 people will die from the disease" and "The number of people living beyond a cancer diagnosis reached nearly 14.5 million in 2014 and is expected to rise to almost 19 million by 2024." The usual treatment for cancer involves surgery, radiation, and chemotherapy. In an effort to reduce the side effects of chemotherapy while increasing its effectiveness, biomaterials are investigated as sustained drug delivery systems for targeted release. Recent studies have demonstrated the ability of custom made bioceramics to provide therapeutic doses of anticancer drug that eradicated tumor cells in vitro and in animal models. The objective of the research work in the present master’s thesis was to develop an injectable formula of bioceramic drug delivery system that can be injected directly into solid tumors. The drug release kinetics from the injectable ceramic was measured and its efficacy has been confirmed.

Details
Author

Haig, James

Title

Development of injectable bioceramic drug delivery system for solid tumor treatment

Physical Description

1 online resource (56 pages) : PDF

Date

2017

Degree Granting Institution

University of North Carolina at Charlotte

Abstract

According to the national cancer institute "In 2016, an estimated 1,685,210 new cases of cancer will be diagnosed in the United States and 595,690 people will die from the disease" and "The number of people living beyond a cancer diagnosis reached nearly 14.5 million in 2014 and is expected to rise to almost 19 million by 2024." The usual treatment for cancer involves surgery, radiation, and chemotherapy. In an effort to reduce the side effects of chemotherapy while increasing its effectiveness, biomaterials are investigated as sustained drug delivery systems for targeted release. Recent studies have demonstrated the ability of custom made bioceramics to provide therapeutic doses of anticancer drug that eradicated tumor cells in vitro and in animal models. The objective of the research work in the present master’s thesis was to develop an injectable formula of bioceramic drug delivery system that can be injected directly into solid tumors. The drug release kinetics from the injectable ceramic was measured and its efficacy has been confirmed.

Genre

masters theses

Subjects--Topics

Materials science
Engineering
Biomedical engineering

Degree

M.S.

Keywords

Bioceramics
Biomaterials
Drug Delivery
Drug Release
Injectability
SCPC

Subject Area

Mechanical Engineering

Advisor(s)

El-Ghannam, Ahmed

Committee Members

Dreau, Didier
Wei, Qiuming

Degree Note

Thesis (M.S.)--University of North Carolina at Charlotte, 2017.

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Rights Holder Information

Copyright is held by the author unless otherwise indicated.

Identifier

Haig_uncc_0694N_11445

Permalink

http://hdl.handle.net/20.500.13093/etd:457