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Genomic alterations and abnormal expression of APE2 in multiple cancers

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Yan, S., Jensen, K. A., & Shi, X. (2020). Genomic alterations and abnormal expression of APE2 in multiple cancers. Scientific Reports. https://doi.org/doi:10.1038/s41598-020-60656-5
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Description

Although APE2 plays essential roles in base excision repair and ATR-Chk1 DNA damage response (DDR) pathways, it remains unknown how the APE2 gene is altered in the human genome and whether APE2 is differentially expressed in cancer patients. Here, we report multiple-cancer analyses of APE2 genomic alterations and mRNA expression from cancer patients using available data from The Cancer Genome Atlas (TCGA). We observe that APE2 genomic alterations occur at ~17% frequency in 14 cancer types (n = 21,769). Most frequent somatic mutations of APE2 appear in uterus (2.89%) and skin (2.47%) tumor samples. Furthermore, APE2 expression is upregulated in tumor tissue compared with matched non-malignant tissue across 5 cancer types including kidney, breast, lung, liver, and uterine cancers, but not in prostate cancer. We also examine the mRNA expression of 13 other DNA repair and DDR genes from matched samples for 6 cancer types. We show that APE2 mRNA expression is positively correlated with PCNA, APE1, XRCC1, PARP1, Chk1, and Chk2 across these 6 tumor tissue types; however, groupings of other DNA repair and DDR genes are correlated with APE2 with different patterns in different cancer types. Taken together, this study demonstrates alterations and abnormal expression of APE2 from multiple cancers.

Details
Title

Genomic alterations and abnormal expression of APE2 in multiple cancers

Author(s)

Yan, Shan
Jensen, Katherine A.
Shi, Xinghua

UNC Charlotte Affiliate Type

Faculty

Publisher

Nature Publishing Group

Extent

1 online resource

Date Published

2020-02-28

Material Type

Journal article

Genre

articles

Resource Type

text

Abstract

Although APE2 plays essential roles in base excision repair and ATR-Chk1 DNA damage response (DDR) pathways, it remains unknown how the APE2 gene is altered in the human genome and whether APE2 is differentially expressed in cancer patients. Here, we report multiple-cancer analyses of APE2 genomic alterations and mRNA expression from cancer patients using available data from The Cancer Genome Atlas (TCGA). We observe that APE2 genomic alterations occur at ~17% frequency in 14 cancer types (n = 21,769). Most frequent somatic mutations of APE2 appear in uterus (2.89%) and skin (2.47%) tumor samples. Furthermore, APE2 expression is upregulated in tumor tissue compared with matched non-malignant tissue across 5 cancer types including kidney, breast, lung, liver, and uterine cancers, but not in prostate cancer. We also examine the mRNA expression of 13 other DNA repair and DDR genes from matched samples for 6 cancer types. We show that APE2 mRNA expression is positively correlated with PCNA, APE1, XRCC1, PARP1, Chk1, and Chk2 across these 6 tumor tissue types; however, groupings of other DNA repair and DDR genes are correlated with APE2 with different patterns in different cancer types. Taken together, this study demonstrates alterations and abnormal expression of APE2 from multiple cancers.

Subjects--Topics

Cancer--Genetic aspects
DNA repair

Is Part Of

Scientific reports

Volume

10

Issue

1

ISSN

2045-2322

Beginning Page Number

1

Ending Page Number

49

Language

English

Published Version (Please cite this version)

doi:10.1038/s41598-020-60656-5

Publisher's Version

https://doi.org/10.1038/s41598-020-60656-5

Permalink

http://hdl.handle.net/20.500.13093/work:95

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