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ENGINEERING OXYGEN TRANSPORT FOR IMPROVING CELL PERFORMANCE IN HEPATIC DEVICES
Title
ENGINEERING OXYGEN TRANSPORT FOR IMPROVING CELL PERFORMANCE IN HEPATIC DEVICES
Author
Shi, Gengbei
Date Created
2012
Description
The bioartificial liver (BAL) advancing medical technology aims to provide temporary liver substitution for patients in dire need of liver transplants and also for drug development. Yet despite nearly fifty years of development, the approval for t...
Hepatic Stellate Cell Transdifferentiation: Pro-fibrogenic Effectors
Title
Hepatic Stellate Cell Transdifferentiation: Pro-fibrogenic Effectors
Author
Lakner, Ashley
Date Created
2011
Description
Hepatic fibrosis is a significant cause of morbidity and mortality worldwide and can be described as exacerbated wound-healing marked by excessive deposition of extracellular matrix components, predominantly type I collagen. Chronic injury stimula...
Hydrogen Sulfide Modulates Hepatic Oxygen Availability and Microcirculation during Sepsis
Title
Hydrogen Sulfide Modulates Hepatic Oxygen Availability and Microcirculation during Sepsis
Author
Norris, Eric
Date Created
2012
Description
A mismatch between O2 supply and demand leads to the development of tissue hypoxia which contributes to hepatic dysfunction and injury during sepsis. Previously, we reported that hepatic microcirculatory failure is a major contributor to hypoxia a...
Interaction between hydrogen sulfide and endothelin-1 in hepatic perfusion and mitochondrial dynamics in endotoxemia
Title
Interaction between hydrogen sulfide and endothelin-1 in hepatic perfusion and mitochondrial dynamics in endotoxemia
Author
Pennington, Samantha
Date Created
2018
Description
A mismatch between oxygen supply and metabolic tissue demand leads to the development of hypoxia, which contributes to hepatic dysfunction and liver injury during sepsis. Recent evidence shows that hepatic H2S levels are increased during sepsis an...
Role of Nonmuscle Myosin II in Hepatic Stellate Cell Activation
Title
Role of Nonmuscle Myosin II in Hepatic Stellate Cell Activation
Author
Moore, Cathy
Date Created
2009
Description
The hepatic stellate cell (HSC) plays a pivotal role in the development of hepatic fibrosis. Regulation of liver microcirculation is a complex system where blood flow is under systemic and sinusoidal control. Upon a fibrogenic stimulus, quiescent ...