Search results | J. Murrey Atkins Library

Title: Analysis and Development of Targeting Strategies for Bacterial Sugars
Author: Erickson, Katelyn
Date Created: 2018
Description: Bacterial cell surface exopolysaccharides aid in protecting microbes from the defense mechanisms of the host, and differ substantially in structure between species. Exploiting these structural differences would be advantageous to target certain ty...

Title: Analysis and Development of Targeting Strategies for Bacterial Sugars
Author: Erickson, Katelyn
Date Created: 2018
Subjects--Topical: Chemistry, Biochemistry
Description: Bacterial cell surface exopolysaccharides aid in protecting microbes from the defense mechanisms of the host, and differ substantially in structure between species. Exploiting these structural differences would be advantageous to target certain ty...

Title: DOPAMINE DETECTION VIA SURFACE ENHANCED RAMAN SCATTERING FOR PARKINSON’S DISEASE
Author: Cutler, Eric
Date Created: 2019
Description: Motion is controlled via the excitatory or inhibitory responses of the motor pathway by receptors in Substantia Nigra of the brain, modulated by a main neurotransmitter dopamine (DA). Parkinson’s Disease (PD) is the neurological disorder effecting...

Title: DOPAMINE DETECTION VIA SURFACE ENHANCED RAMAN SCATTERING FOR PARKINSON’S DISEASE
Author: Cutler, Eric
Date Created: 2019
Subjects--Topical: Mechanical engineering, Biomedical engineering
Description: Motion is controlled via the excitatory or inhibitory responses of the motor pathway by receptors in Substantia Nigra of the brain, modulated by a main neurotransmitter dopamine (DA). Parkinson’s Disease (PD) is the neurological disorder effecting...

Title: Development of Silica Based Nanoparticles for Multimodal Therapeutic Delivery
Author: Vadarevu, Hemapriyadarshini
Date Created: 2022
Subjects--Topical: Nanoscience
Description: Chronic diseases like cancer are characterized by complex interactions between multiple pathways leading to treatment resistance and invasiveness. Repeated cycles of cytotoxic monotherapies are susceptible to drug resistance induced by the upregul...

Title: Development of nanoparticle-based approaches for the treatment and imaging of pancreatic cancer
Author: Tarannum, Mubin
Date Created: 2020
Description: Pancreatic ductal adenocarcinoma (PDAC) is a type of exocrine pancreatic cancer which accounts for over 90% of cases. PDAC is the fourth-leading cause of cancer-related mortality in the United States with a 5-year survival rate of 9% with little t...

Title: Development of nanoparticle-based approaches for the treatment and imaging of pancreatic cancer
Author: Tarannum, Mubin
Date Created: 2020
Subjects--Topical: Nanoscience, Chemistry
Description: Pancreatic ductal adenocarcinoma (PDAC) is a type of exocrine pancreatic cancer which accounts for over 90% of cases. PDAC is the fourth-leading cause of cancer-related mortality in the United States with a 5-year survival rate of 9% with little t...

Title: ELUCIDATING THE MOLECULAR BASIS OF INHIBITION OF ENZYMES ESSENTIAL FOR BATERIALVIRULENCE: THE ACTIVITY OF THREE GLYCOSYLTRANSFERASES AND A POTENTIAL DRUG TARGET, UNDECAPRENYL PYROPHOSPHATE SYNTHASE
Author: Okwei, Elleansar
Date Created: 2016
Description: The fight against bacterial infection is one of the most important branches of modern medicine. Due to the emergence of strains of antibiotic-resistant bacteria, researchers have been presented with complex challenges in an effort to combat these ...

Title: ELUCIDATING THE MOLECULAR BASIS OF INHIBITION OF ENZYMES ESSENTIAL FOR BATERIALVIRULENCE: THE ACTIVITY OF THREE GLYCOSYLTRANSFERASES AND A POTENTIAL DRUG TARGET, UNDECAPRENYL PYROPHOSPHATE SYNTHASE
Author: Okwei, Elleansar
Date Created: 2016
Subjects--Topical: Chemistry, Biology, Biochemistry
Description: The fight against bacterial infection is one of the most important branches of modern medicine. Due to the emergence of strains of antibiotic-resistant bacteria, researchers have been presented with complex challenges in an effort to combat these ...

Title: Folate Receptor-Specific, Redox-Responsive Mesoporous Silica Nanoparticles for the Simultaneous Delivery of Cisplatin and Gemcitabine to Treat Cancer
Author: Fink, Eric
Date Created: 2016
Description: Nanoparticles are an innovative platform for cancer treatment that reduces systemic toxicity and allows for active targeting of tumor sites to enhance the therapeutic efficacy. Mesoporous silica nanoparticles (MSNs) have emerged as an attractive d...

Title: Folate Receptor-Specific, Redox-Responsive Mesoporous Silica Nanoparticles for the Simultaneous Delivery of Cisplatin and Gemcitabine to Treat Cancer
Author: Fink, Eric
Date Created: 2016
Subjects--Topical: Materials science, Chemistry, Biochemistry
Description: Nanoparticles are an innovative platform for cancer treatment that reduces systemic toxicity and allows for active targeting of tumor sites to enhance the therapeutic efficacy. Mesoporous silica nanoparticles (MSNs) have emerged as an attractive d...

Title: INCORPORATION OF FLUORESCENT ANALOGUES IN ISOPRENOID PATHWAYS IN ESCHERICHIA COLI
Author: George, Chelsea
Date Created: 2018
Description: Bacterial glycans and glycoconjugates have wide diversity compared to their eukaryotic counterparts. While methods have been developed to monitor and track glycans in eukaryotic systems with some success, there are limited methods with which to do...

Title: INCORPORATION OF FLUORESCENT ANALOGUES IN ISOPRENOID PATHWAYS IN ESCHERICHIA COLI
Author: George, Chelsea
Date Created: 2018
Subjects--Topical: Biochemistry
Description: Bacterial glycans and glycoconjugates have wide diversity compared to their eukaryotic counterparts. While methods have been developed to monitor and track glycans in eukaryotic systems with some success, there are limited methods with which to do...

Title: Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
Author: Suptela, Alexander
Date Created: 2023
Subjects--Topical: Immunology, Molecular biology, Neurosciences
Description: Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses (DDRs) is a critical step in maintaining genomic int...

Title: The Application of Light-Assisted Drying to the Thermal Stabilization of Nucleic Acid Nanoparticles
Author: Lam, Phuong Anh
Date Created: 2021
Subjects--Topical: Physics
Description: Cold storage can be challenging and expensive for the transportation and storage of biologics. We are developing a new processing technique, light-assisted drying (LAD), to prepare biologics for anhydrous storage in a trehalose amorphous solid mat...

Title: The Role of MicroRNA-26a In Skeletal Muscle Insulin Signaling
Author: Petrocelli, Jonathan
Date Created: 2018
Description: Chronic saturated fatty acid exposure causes skeletal muscle cells to develop insulin resistance, which contributes to the pathogenesis of type 2 diabetes mellitus. Recently, microRNAs have been viewed as novel molecules that contribute to the reg...

Title: The Role of MicroRNA-26a In Skeletal Muscle Insulin Signaling
Author: Petrocelli, Jonathan
Date Created: 2018
Subjects--Topical: Kinesiology
Description: Chronic saturated fatty acid exposure causes skeletal muscle cells to develop insulin resistance, which contributes to the pathogenesis of type 2 diabetes mellitus. Recently, microRNAs have been viewed as novel molecules that contribute to the reg...

Title: Understanding Chaperone interactions in disease
Author: Nitika
Date Created: 2021
Description: The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key player in proteostasis, deciding which proteins are foldable and which are too...

Title: Understanding Chaperone interactions in disease
Author: Nitika
Date Created: 2021
Subjects--Topical: Molecular biology, Biochemistry, Cytology
Description: The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key player in proteostasis, deciding which proteins are foldable and which are too...