Search results | J. Murrey Atkins Library

Title: A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
Author: Wu, Shuta
Date Created: 2017
Description: Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...

Title: A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
Author: Wu, Shuta
Date Created: 2017
Subjects--Topical: Biology, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...

Title: Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
Author: Bose, Mukulika
Date Created: 2022
Subjects--Topical: Molecular biology, Biochemistry, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...

Title: CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
Author: Knighton, Laura
Date Created: 2020
Description: The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...

Title: CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
Author: Knighton, Laura
Date Created: 2020
Subjects--Topical: Biology, Biochemistry
Description: The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...

Title: Characterizing a New Regulator of the ATR Signaling Pathway
Author: Biller, Megan
Date Created: 2022
Subjects--Topical: Molecular biology, Biology
Description: Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...

Title: Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Author: Vestal, Carol
Date Created: 2016
Description: Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...

Title: Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Author: Vestal, Carol
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...

Title: EVALUATING BIOFLAVONOID INDUCED DNA DOUBLE-STRAND BREAKS AND CHROMOSOMAL TRANSLOCATIONS
Author: Goodenow, Donna
Date Created: 2020
Description: Dietary bioflavonoids are a class of chemical compounds found in soy, fruits, vegetables, tea, coffee, wine, and dietary supplements. They are separated into 12 different sub-classes based upon their structure, however only six are dietarily relev...

Title: EVALUATING BIOFLAVONOID INDUCED DNA DOUBLE-STRAND BREAKS AND CHROMOSOMAL TRANSLOCATIONS
Author: Goodenow, Donna
Date Created: 2020
Subjects--Topical: Biology
Description: Dietary bioflavonoids are a class of chemical compounds found in soy, fruits, vegetables, tea, coffee, wine, and dietary supplements. They are separated into 12 different sub-classes based upon their structure, however only six are dietarily relev...

Title: Evolution and dynamics of transcriptional regulation in bacteria
Author: Li, Shan
Date Created: 2013
Description: Although transcription is one of the most important biological functions of cells, our understanding of its regulation is still limited. In this dissertation, we have studied the transcriptional regulation in prokaryotes in three aspects. First, w...

Title: Evolution and dynamics of transcriptional regulation in bacteria
Author: Li, Shan
Date Created: 2013
Subjects--Topical: Computer science, Statistics, Bioinformatics
Description: Although transcription is one of the most important biological functions of cells, our understanding of its regulation is still limited. In this dissertation, we have studied the transcriptional regulation in prokaryotes in three aspects. First, w...

Title: Hydrogen bond energy-based comparative analysis of protein-ligand interactions and similarity assessment of protein-DNA complex models
Author: Malik, Fareeha
Date Created: 2022
Subjects--Topical: Bioinformatics, Computer science
Description: Hydrogen bonds play a vital role in protein-DNA interactions. In particular, side chain-base hydrogen bonds are crucial to the binding specificity between protein and DNA. Mutations effecting interface hydrogen bonds in protein-DNA complexes have ...

Title: Insights Into Plasmodium Genetic Changes Related To Malaria Interventions
Author: Dieng, Cheikh
Date Created: 2023
Subjects--Topical: Biology, Parasitology, Genetics
Description: Over 80% of all malaria deaths occur in children under 5 years of age. Malaria controlstrategies have been progressively shifted to specific populations and/or areas to maximize effectiveness. Malaria is a significant public health problem in Ghan...

Title: PRESERVING DIFFERENTIAL PRIVACY IN COMPLEX DATA ANALYSIS
Author: Wang, Yue
Date Created: 2015
Description: Omnipresent databases from various resources, such as social networks, electronic commercial websites, and health related wearable devices, have provided researchers with unprecedented opportunities to analyze complex social phenomena. While socie...

Title: PRESERVING DIFFERENTIAL PRIVACY IN COMPLEX DATA ANALYSIS
Author: Wang, Yue
Date Created: 2015
Subjects--Topical: Computer science, Data sets
Description: Omnipresent databases from various resources, such as social networks, electronic commercial websites, and health related wearable devices, have provided researchers with unprecedented opportunities to analyze complex social phenomena. While socie...

Title: Polymer Mediated Delivery of Oligonucleotide and Trans Genes Toward More Efficient and Specific Therapies for Dystrophinopathies and Dystroglycanopathies
Author: Tucker, Jason
Date Created: 2014
Description: Muscular dystrophies are genetic disorders caused by mutations in more than 30 genes, with no cure or effective treatment. Duchenne muscular dystrophy (DMD) is caused by frame-shift mutations in the dystrophin gene with little or no functional dys...

Title: Polymer Mediated Delivery of Oligonucleotide and Trans Genes Toward More Efficient and Specific Therapies for Dystrophinopathies and Dystroglycanopathies
Author: Tucker, Jason
Date Created: 2014
Description: Muscular dystrophies are genetic disorders caused by mutations in more than 30 genes, with no cure or effective treatment. Duchenne muscular dystrophy (DMD) is caused by frame-shift mutations in the dystrophin gene with little or no functional dys...

Title: Polymer Mediated Delivery of Oligonucleotide and Trans Genes Toward More Efficient and Specific Therapies for Dystrophinopathies and Dystroglycanopathies
Author: Tucker, Jason
Date Created: 2014
Subjects--Topical: Molecular biology, Biology, Neurosciences
Description: Muscular dystrophies are genetic disorders caused by mutations in more than 30 genes, with no cure or effective treatment. Duchenne muscular dystrophy (DMD) is caused by frame-shift mutations in the dystrophin gene with little or no functional dys...

Title: Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
Author: Suptela, Alexander
Date Created: 2023
Subjects--Topical: Immunology, Molecular biology, Neurosciences
Description: Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses (DDRs) is a critical step in maintaining genomic int...