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Title: Disulfide-trapped CXCL12-CXCL4 Chemokine Heterodimers Prevent Breast Cancer Progression
Author: Nguyen, Khanh
Date Created: 2021
Subjects--Topical: Biology
Description: Triple negative breast cancers (TNBCs), i.e., 10-15% of diagnosed breast cancers, have a triple negative (Her/2-, ER- and PR-) phenotype and are the most aggressive subtype of breast cancer. TNBCs have a worst prognosis because of the high probabi...

Title: PROTEIN-PROTEIN INTERACTION OF PAI-H19Y MUTANT OF THE SLEEPING BEAUTY TRANSPOSASE
Author: Yan, Chenbo
Date Created: 2020
Description: Due to the substantial interest in developing transposon technology for gene delivery and gene therapy, the Sleeping Beauty (SB) transposon system, the most active transposon in the vertebrate species, has been extensively studied. The SB transpos...

Title: PROTEIN-PROTEIN INTERACTION OF PAI-H19Y MUTANT OF THE SLEEPING BEAUTY TRANSPOSASE
Author: Yan, Chenbo
Date Created: 2020
Subjects--Topical: Biophysics, DNA
Description: Due to the substantial interest in developing transposon technology for gene delivery and gene therapy, the Sleeping Beauty (SB) transposon system, the most active transposon in the vertebrate species, has been extensively studied. The SB transpos...

Title: Quantifying the Binding Affinities of the PAI-H19Y Mutant of Sleeping Beauty Transposase to DNA
Author: Arango, Maria
Date Created: 2022
Subjects--Topical: Physics
Description: The Sleeping Beauty (SB) transposon system is the leading and only DNA transposon-based gene-delivery vehicle that has been adapted for human gene therapy. The SB system consists of a transposon DNA flanked by inverted terminal repeats (ITRs) and ...

Title: STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE H19Y MUTATED PRIMARY DNA RECOGNITION SUBDOMAIN OF SLEEPING BEAUTY TRANSPOSASE
Author: Leighton, Gage
Date Created: 2017
Description: The Sleeping Beauty transposon system, consisting of the transposon DNA and the transposase enzyme, is a member of the Tc1/mariner family of DNA transposons. Although it is an important tool in genetic applications and has been adapted for human g...

Title: STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE H19Y MUTATED PRIMARY DNA RECOGNITION SUBDOMAIN OF SLEEPING BEAUTY TRANSPOSASE
Author: Leighton, Gage
Date Created: 2017
Subjects--Topical: Physics, Chemistry, Physical and theoretical, Biophysics
Description: The Sleeping Beauty transposon system, consisting of the transposon DNA and the transposase enzyme, is a member of the Tc1/mariner family of DNA transposons. Although it is an important tool in genetic applications and has been adapted for human g...